Teratogenicity of antibacterial drugs

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Teratogenicity of antibacterial agents.

The aim of our study was to study the possible correlation between use of antibacterial drugs in pregnancy and occurrence of congenital malformations. Among 6099 investigated pregnant women, 392 (6.43%) used antibacterial drugs. The most frequently used antibacterials belonged to category B (75.77%), while 14.54% antibiotics belonged to category D and 1.02% to category X. The most often used an...

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Teratogenicity of Antiepileptic Drugs

Objective Antiepileptic drugs (AED) have chronic teratogenic effects, the most common of which are congenital heart disease, cleft lip/palate, urogenital and neural tube defects. The aim of our study is to examine teratogenic effects of AED and the correlation between these malformations and AED in single or multiple pregnancies. Methods This is a retrospective study of malformations in child...

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Comparative Teratogenicity of Alcohol and Other Drugs

The National Institute on Drug Abuse (NIDA) conducted a national household survey of drug use in 1990, completing interviews with 9,259 people. Of all women surveyed, 78.7 percent reported they had drunk alcohol in their lifetime (NIDA 1991a). Sixty­one percent drank in the past year, and 44.1 percent drank in the past month. Women were generally light drinkers: 19 percent drank less often than...

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Common Mechanism for Teratogenicity of Antiepileptic Drugs

Azarbayjani, F. 2001. Common mechanism for teratogenicity of antiepileptic drugs. Drug induced embryonic arrhythmia and hypoxia-reoxygenation damage. Acta Universitatis Upsaliensis. Comprehensive Summaries of Uppsala Dissertations from the Faculy of Pharmacy 253. 54 pp. Uppsala.

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Appropriate Targets for Antibacterial Drugs.

Successful small-molecule antibacterial agents must meet a variety of criteria. Foremost is the need for selectivity and safety: It is easy to kill bacteria with chemicals, but difficult to do it without harming the patient. Other requirements are possession of a useful antibacterial spectrum, no cross-resistance with existing therapeutics, low propensity for rapid resistance selection, and pha...

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ژورنال

عنوان ژورنال: Frontiers in Pharmacology

سال: 2010

ISSN: 1663-9812

DOI: 10.3389/conf.fphar.2010.60.00192